Objective: To analyze the application value of body temperature protection measures for patients undergoing trans-left-chest surgery for esophageal cancer. Methods: A total of 40 patients undergoing left sided trans-thoracic radical resection of esophageal cancer under general anesthesia in the Affiliated Hospital of Jiangnan University from January to December 2019 were selected as the subjects for this study. They were randomly divided into an experimental group (who received intervention with body temperature protection) and a control group (who received routine intervention). The nasopharyngeal temperature, extubation time, lactic acid value in arterial blood gases, and the incidence of complications at each time point were observed for both groups. Results: Various body temperatures at 1 h postoperatively, extubation time, and lactic acid at extubation showed statistically significant differences between the experimental group and the control group (P<0.05). Conclusion: Body temperature protection presents good clinical application value for palinesthesia and microcirculation following trans-left-chest surgery for esophageal cancer.