Objective: To explore the effect of nursing intervention based on “functional health type” on the psychological resilience and sleep quality of AIDS patients. Methods: A total of 100 AIDS patients admitted to our hospital from December 2019 to October 2020 were included and randomly divided into an experimental group and a control group with 50 cases in each group. Patients in the control group were given routine nursing interventions, and patients in the experimental group was given nursing interventions based on “functional health patterns”. The Connor-Davidson Resilience Scale (CD-RISC) was used to evaluate the psychological resilience of the patients and the Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of the patients. The psychological elasticity and sleep quality of the two groups of patients were compared. Results: The nursing needs of the experimental group were evaluated by functional health style. The results showed that the problems of self-perception and self-concept, stress and coping were serious in the experimental group. The resilience, resilience, strength, optimism, and CD-RISC total score of experimental were higher than those of the control group, and the difference was statistically significant (P<0.05). The daytime function, hypnotic drugs, sleep disorders, sleep efficiency, sleep time, time to fall asleep, sleep quality and PSQI total scores of the experimental group were lower than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion: The nursing intervention based on “functional health type” can effectively assess the nursing needs of AIDS patients, guide patients to correctly understand the treatment process of AIDS, and provide patients with treatment means, treatment information and nursing knowledge, conducive to improving patients’ psychological resilience and sleep quality.