肠道微生物群落与银屑病炎症细胞因子的相关研究进展
| 作者: |
1王轩,
1胡慧敏,
1许辉,
1李遇梅
1 江苏大学附属医院皮肤科，江苏 镇江 212001 |
| 通讯: |
许辉
Email: xuhuiraian@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.04.034 |
| 基金: | 江苏省妇幼健康科研项目(F201717)；江苏省预防医学课题(Y2018107)；镇江市社会发展项目(SH2018032)；江苏大学附属医院博士启动基金(jdfyrc2019003)。 |
摘要
银屑病是一种免疫介导的炎症性皮肤病，影响着全世界1%~3%的人口。银屑病的发病机制是多因 素的，遗传和环境因素对银屑病均有显著影响。研究表明肠道微生物群落及相关炎症细胞因子与 银屑病的发生和发展密切相关。然而银屑病的发病机制，特别是与肠道微生物群落的相关性，目 前仍不明确。本文就肠道微生物群落紊乱，IL-17A、IL-22、TNF-α等相关炎症细胞因子与银屑病 发病机制的联系作一综述。
关键词：
银屑病；肠道微生物群落；细胞因子；免疫；治疗
Correlation between intestinal microbial community and psoriasis related inflammatory cytokines
CorrespondingAuthor: XU Hui Email: xuhuiraian@sina.com
DOI: 10.3978/j.issn.2095-6959.2022.04.034
Foundation: This work was supported by the Maternal and Child Health Project of Jiangsu Province (F201717), Jiangsu Provincial Preventive Medicine Project (Y2018107), Zhenjiang Social Development Project (SH2018032), and the Doctoral Foundation of the Affiliated Hospital of Jiangsu University (jdfyrc2019003), China.
Abstract
Psoriasis is an immune-mediated inflammatory skin disease that affects 1%–3% of the world’s population. The pathogenesis of psoriasis is multifactorial. Both genetic and environmental factors have significant influence on psoriasis. Recent studies have shown that intestinal microbial community and related inflammatory cytokines are closely related to the occurrence and development of psoriasis. However, the pathogenesis of psoriasis, especially its correlation with intestinal microbial community, is still not fully understood. This review summarizes and analyzes the relationship between intestinal microbial community, IL-17A, IL-22, TNF-α and other inflammatory cytokines and the pathogenesis of psoriasis.
Keywords：
psoriasis; intestinal microbial community; cytokine; immunity; treatment