Objective: To investigate the correlation between the quality of life after laparoscopic myomectomy and the operation status and main complaints. Methods: A total of 112 patients who underwent laparoscopic myomectomy from January 2018 to January 2019 in Wuxi Maternal and Child Health Hospital were selected. The clinical data of all patients were retrospectively analyzed, and the European Five-Dimensional Health Scale (EQ-5D-5L) Evaluate the patient’s quality of life on the 3rd, 7th, 14th, 21th, 28th postoperatively, and analyze the patient’s operation time, intraoperative blood loss, number of fibroids, maximum fibroids diameter, and the correlation between complaints and quality of life. Results: The quality of life scores of 112 patients were 0.58±0.16, 0.73±0.60, 0.87±0.31, 0.94±0.28 and 0.97±0.19. On the 3rd, 7th, and 14th day after operation, the quality of life of patients with different complaints gradually improved (all P<0.05). There was no significant correlation between the quality of life on the 3rd and 7th day of 112 patients after operation, the amount of blood loss, the number of fibroids, or the largest fibroids diameter (all P>0.05); on the 14th day after operation, the quality of life was negatively correlated with the number and volume of myoma (P<0.05); there was no significant correlation between the quality of life of 112 patients on the 3rd, 7th, and 14th days after operation with increased menstrual flow, prolonged menstrual period, pain, infertility, and history of abdominal surgery (P>0.05). Conclusion: The quality of life of patients with laparoscopic myomectomy is basically restored at 2 weeks postoperatively, which is only negatively correlated with the number of fibroids, and has no significant correlation with the main complaint symptoms.