环状RNA：肝纤维化相关疾病的病理新机制
| 作者: |
1罗鲲鹏,
2梁美惠,
1金世柱
1 哈尔滨医科大学附属第二医院消化内科，哈尔滨 150081 2 新疆生产建设兵团第十师北屯医院功能科，新疆 北屯 830000 |
| 通讯: |
金世柱
Email: drshizhujin@hrbmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2021.11.030 |
| 基金: | 新疆生产建设兵团重点领域科技攻关计划(2020AB020)。 |
摘要
肝纤维化相关疾病是一组发病率高、病因复杂、预后不良的疾病，但其发生机制尚不明，对于已经形成的肝纤维化病变也缺乏有效的逆转手段。最新研究发现环状RNA(circular RNA，circRNA)在肝纤维化及其相关疾病的发生、发展中起重要的调控作用。本文综述了circRNA在肝组织中的表达及其在肝纤维化过程中的调控作用、其在肝纤维化相关疾病中的调控作用、作用机制和差异性表达情况，以期为其在临床上相关疾病的靶向治疗研究提供新思路，为临床诊断寻找新的生物学标志物。
关键词：
环状RNA；肝纤维化；治疗靶点；诊断标志物；病理机制
CircRNA: A new pathological mechanism of hepatic fibrotic disease
CorrespondingAuthor: JIN Shizhu Email: drshizhujin@hrbmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2021.11.030
Foundation: This work was supported by the Key Scientific and Technological Research Plan of Xinjiang Production and Construction Corps, China (2020AB020).
Abstract
Liver fibrosis related diseases are a group of diseases with high incidence rate, complex etiology, and poor prognosis. However, the pathogenesis is still unknown, and there is also a lack of effective means for the reversal of liver fibrosis. Recent studies have found that circular RNA (circRNA) plays an important regulatory role in the occurrence and development of liver fibrosis and its related diseases. In order to provide new ideas for the targeted treatment of clinical related diseases, and find new biological markers for clinical diagnosis, this paper reviews the expression of circRNA in liver tissue, its regulatory role in the process of liver fibrosis, its regulatory role, mechanism and differential expression in liver fibrosis related diseases.
Keywords：
circular RNA; liver fibrosis; therapeutic target; diagnostic markers; pathological mechanism