Condyloma acuminatum (CA) is a sexually transmitted disease caused by human papillomavirus (HPV) infection, manifested as benign verrucous hyperplastic lesions of the genitourinary, perianal skin, and mucous membranes. The basic treatment of CA is to remove visible warts, such as the use of topical drugs (trichloroacetic acid, imiquimod, etc.), and physical therapy [liquid nitrogen freezing, carbon dioxide (CO2) laser, surgical resection, etc.]. Although CA patients have been treated to remove the warts, they still have a higher recurrence rate in clinic. The repeated attacks of CA affect the patient's physical and mental health and cause great pressure on the economy and life. Common relapse factors of CA include subclinical infection status, individual factors (bad living habits, low immunity, excessive foreskin, etc.), HPV related factors, wart body factors, treatment methods, etc. At present, we have realized the importance of prevention of CA recurrence in clinical practice, and now we have adopted many ways to prevent CA recurrence, including removing warts with traditional Chinese medicine, self-wart implantation, combined use of interferon, 5-aminolevulinic acid + photodynamic (ALA + PDT), etc. In this paper, the pathogenesis, recurrence factors and treatment of recurrent CA were reviewed in order to provide reference for clinical work and reduce the recurrence rate of CA.