环状RNA在肿瘤免疫中的研究进展
| 作者: |
1赵国云,
1朱梦迪,
1孙宇辉
1 哈尔滨医科大学附属第一医院妇产科，哈尔滨 150000 |
| 通讯: |
孙宇辉
Email: yuhui_sun@vip.163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.031 |
| 基金: | 哈尔滨医科大学附属第一医院科研创新基金 (2020M08)。 |
摘要
非编码RNA(non-coding RNA，ncRNA)可以分为环状RNA(circular RNA，circRNA)和线性ncRNA。ncRNA存在于不同的细胞类型中，包括正常细胞、肿瘤细胞和免疫细胞等。目前已经发现线性ncRNA，如长链非编码RNA(long noncoding RNA，lncRNA)和微RNA(microRNA，miRNA)，在调节肿瘤免疫和免疫治疗中起重要作用。但是，circRNA在肿瘤免疫和免疫治疗中的功能鲜为人知。
关键词：
环状RNA；非编码RNA；微RNA；肿瘤免疫；靶向治疗
Research progress of circular RNA in tumor immunity
CorrespondingAuthor: SUN Yuhui Email: yuhui_sun@vip.163.com
DOI: 10.3978/j.issn.2095-6959.2022.03.031
Foundation: This work was supported by Research and Innovation Fund of the First Affiliated Hospital of Harbin Medical University, China (2020M08).
Abstract
Non-coding RNA (ncRNA) can be divided into circular non-coding RNA (circRNA) and linear ncRNA. ncRNA exists in different cell types, including normal cells, tumor cells and immune cells. It has been found that linear ncRNA, such as long noncoding RNA (lncRNA) and microRNA (miRNA), plays an important role in regulating tumor immunity and immunotherapy. However, it’s rarely known about the role of circRNA in tumor immunity.
Keywords：
circular RNA; non-coding RNA; microRNA; tumor immunity; targeted therapy