过氧化物氧还原蛋白酶1在炎症相关疾病中的研究
| 作者: |
1,2胡成云,
3张哲弢,
2唐朝亮
1 皖南医学院，安徽 芜湖 241002 2 中国科学技术大学附属第一医院麻醉科，合肥 230001 3 中国科学技术大学附属第一医院药剂科，合肥 230036 |
| 通讯: |
唐朝亮
Email: chaolt@ustc.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2022.03.032 |
| 基金: | 国家自然科学基金 (81801175)；中国博士后科学基金 (2019M662179)；安徽省博士后研究人员科研活动 经费 (2019B324)；中央高校基本科研业务费专项资金 (WK9110000044)。 |
摘要
过氧化物氧还原蛋白酶(peroxiredoxin 1，Prdx1)作为普遍存在且高度保守的抗氧化蛋白超家族成员，在哺乳动物中含量最高且组织分布最广泛，是最受关注的抗氧化因子之一。Prdx1是一种抗氧化剂，同时兼具分子伴侣的功能，广泛参与体内各器官、细胞的抗氧化应激过程。人体疾病的进展过程中普遍存在炎症，Prdx1在神经系统、消化系统、循环系统及呼吸系统等炎症性疾病以及感染性疾病的发生发展过程中扮演重要角色。
关键词：
Prdx1；炎症；活性氧；氧化应激
Research on peroxiredoxin 1 in inflammation-related diseases
CorrespondingAuthor: TANGChaoliang Email: chaolt@ustc.edu.cn
DOI: 10.3978/j.issn.2095-6959.2022.03.032
Foundation: This work was supported by the National Natural Science Foundation of China (81801175), the China Postdoctoral Science Foundation (2019M662179), the Anhui Provincial Postdoctoral Science Foundation (2019B324), and the Fundamental Research Funds for the Central Universities (WK9110000044), China.
Abstract
As a ubiquitous and highly conserved member of the antioxidant protein superfamily, peroxiredoxin 1 (Prdx1) has the highest content and the most extensive tissue distribution in mammals and is one of the most concerned antioxidant factors. Prdx1 is an antioxidant and has the function of molecular chaperones, which makes it widely involved in the process of anti-oxidative stress in various organs and cells in the body. Inflammation is commonly involved in the progression of human diseases. Prdx1 plays important role in the occurrence and development of inflammatory diseases in the nervous system, digestive system, circulatory system, and respiratory system, and of infectious diseases.
Keywords：
peroxiredoxin 1; inflammation; reactive oxygen species; oxidative stress