Objective: To investigate the effect of sevoflurane combined with cisbenzenesulfonate atracurium on the anesthetic effect and immune function of elderly patients undergoing laparoscopic bowel cancer surgery. Methods: From January 2018 to December 2019, 80 elderly patients undergoing laparoscopic bowel cancer surgery at Baoshan Hospital of Integrated Traditional Chinese and Western Medicine were selected. They were divided into two groups according to the principle of random allocation by computer. The control group (n=40) received propofol combined with fentanyl anesthesia, and the study group (n=40) was anesthetized with cisbenzenesulfonate atracurium on the basis of the control group. The surgical indicators, postoperative recovery status, immune indicators, interleukin-6 (IL-6) levels and adverse reactions were compared between the two groups. Results: The operation indexes of the study group were significantly better than those of the control group, and the recovery time of spontaneous breathing, recovery time, extubation time and orientation recovery time of the study group were shorter than those of the control group (P<0.05); 24 h after operation, the levels of CD3+, CD4+, CD4+/CD8+ of the study group were higher than those of the control group, and the levels of IL-6 were lower than those of the control group, and the differences were statistically significant (P<0.05). CD8+ levels and incidence of adverse reactions rate between the two groups were not statistically significant (P>0.05). Conclusion: Sevoflurane combined with cisbenzenesulfonate atracurium for the anesthesia of elderly patients during laparoscopic bowel cancer surgery can effectively improve the surgical treatment effect and postoperative recovery, and reduce the suppression degree of the immune function, The treatment safety is ideal, and it can be widely used in clinical practice.