文章摘要

泰必利联合心理行为治疗对学龄期抽动秽语综合征患儿的影响

作者: 1吴霞, 1张晓鸥, 1朱小波
1 如皋市人民医院儿科,江苏 如皋 226500
通讯: 吴霞 Email: gllsyc2020@163.com
DOI: 10.3978/j.issn.2095-6959.2021.05.011

摘要

目的:探讨泰必利联合心理行为治疗对学龄期抽动秽语综合征患儿异常行为及脑电图(electroencephalogram,EEG)改变的影响。方法:选取2017年1月至2020年5月于如皋市人民医院门诊治疗的80例抽动秽语综合征患儿。采用随机数表法将患者随机分为对照组与观察组,各40例。观察组给予泰必利结合心理行为治疗,对照组仅口服泰必利,对比两组患儿疗效、异常行为、EEG改变和不良反应。结果:治疗后,观察组总有效率显著高于对照组(χ2=4.020,P=0.045),异常行为评定量表和问卷调查评分较对照组均有显著改善,差异具有统计学意义(P<0.05);两组患者EEG明显改善,观察组EEG改善明显优于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论:泰必利联合心理行为可有效改善学龄期抽动秽语综合征患儿异常行为及EEG,值得临床推广和应用。
关键词: 泰必利;心理行为治疗;抽动秽语综合征;异常行为;脑电图

Effect of tiapride combined with psychobehavioral therapy on abnormal behavior and electroencephalogram changes in school-age children with Tourette’s syndrome

Authors: 1WU Xia, 1ZHANG Xiaoou, 1ZHU Xiaobo
1 Department of Pediatrics, Rugao People’s Hospital, Rugao Jiangsu 226500, China

CorrespondingAuthor: WU Xia Email: gllsyc2020@163.com

DOI: 10.3978/j.issn.2095-6959.2021.05.011

Abstract

Objective: To investigate the effect of tiapride combined with psychobehavioral therapy on abnormal behavior and electroencephalogram (EEG) changes in school-age children with Tourette’s syndrome. Methods: We selected 80 children with Tourette’s syndrome who received outpatient treatment at Rugao People’s Hospital from May 2017 to May 2020. The patients were randomly divided into a control group and a observation group, 40 cases in each group. The observation group was given tiapride combined with psychobehavioral therapy and the control group was only given tiapride orally. The efficacy, abnormal behavior, EEG changes and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group (χ2=4.020; P=0.045); the abnormal behavior evaluation scale and the questionnaire score of the observation group improved significantly compared with the control group, and the difference was statistically significant (P<0.05). EEG was significantly improved in the two groups, and the EEG was significantly better in the observation group than in the control group. The difference was statistically significant (P<0.05); The total incidence of adverse reaction in the observation group was lower than in the control group, and the difference was statistically significant (P<0.05). Conclusion: Tiapride combined with psychobehavioral therapy can effectively improve the abnormal behavior and EEG in school-age children with Tourette’s syndrome, which is worthy of clinical promotion and application.
Keywords: tiapride; psychological behaviour therapy; Tourette’s syndrome; abnormal behaviour; electroencephalogram