Objective: To investigate the effect of tiapride combined with psychobehavioral therapy on abnormal behavior and electroencephalogram (EEG) changes in school-age children with Tourette’s syndrome. Methods: We selected 80 children with Tourette’s syndrome who received outpatient treatment at Rugao People’s Hospital from May 2017 to May 2020. The patients were randomly divided into a control group and a observation group, 40 cases in each group. The observation group was given tiapride combined with psychobehavioral therapy and the control group was only given tiapride orally. The efficacy, abnormal behavior, EEG changes and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group (χ2=4.020; P=0.045); the abnormal behavior evaluation scale and the questionnaire score of the observation group improved significantly compared with the control group, and the difference was statistically significant (P<0.05). EEG was significantly improved in the two groups, and the EEG was significantly better in the observation group than in the control group. The difference was statistically significant (P<0.05); The total incidence of adverse reaction in the observation group was lower than in the control group, and the difference was statistically significant (P<0.05). Conclusion: Tiapride combined with psychobehavioral therapy can effectively improve the abnormal behavior and EEG in school-age children with Tourette’s syndrome, which is worthy of clinical promotion and application.