文章摘要

p63阳性的弥漫大B细胞淋巴瘤1例并文献复习

作者: 1曹石, 1王芳
1 兰州大学第一医院病理科,兰州 730000
通讯: 王芳 Email: 863080751@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.03.038

摘要

弥漫大B细胞淋巴瘤是最常见的非霍奇金淋巴瘤,p63在弥漫大B细胞淋巴瘤中可表达,因此在临床上易被误诊为p63阳性的上皮源性恶性肿瘤,尤其在淋巴结发生转移时。本研究报道1例以呼吸道症状为首发症状的弥漫大B细胞淋巴瘤患者,临床高度怀疑肺恶性肿瘤并淋巴结转移。行右腋窝淋巴结穿刺活检病理诊断,结果显示p63阳性,提示为鳞状细胞癌,而完善免疫组织化学检查后,最终诊断为弥漫大B细胞淋巴瘤。因此,认识p63阳性的弥漫大B细胞淋巴瘤很有必要,可减小临床误诊的可能性。
关键词: p63;弥漫大B细胞淋巴瘤;淋巴瘤;个案报道

p63-positive diffuse large B-cell lymphoma: A case report and literature review

Authors: 1CAO Shi, 1WANG Fang
1 Department of Pathology, First Hospital of Lanzhou University, Lanzhou 730000, China

CorrespondingAuthor: WANG Fang Email: 863080751@qq.com

Abstract

Diffuse large B-cell lymphoma is the most common non-Hodgkin’s lymphoma. p63 is expressed in diffuse large B-cell lymphoma, which may be misdiagnosed as a p63-positive epithelial malignant tumor, especially when lymph node metastasis occurs. The study reported a patient with diffuse large B-cell lymphoma with respiratory symptoms as the first symptom. There is a high clinical suspicion of lung malignancy and lymph node metastasis. In the pathological diagnosis of right axillary lymph node biopsy, a positive p63 suggested squamous cell carcinoma, and the final diagnosis was diffuse large B-cell lymphoma after perfect immunohistochemical examination. Therefore, it is necessary to recognize p63-positive diffuse large B-cell lymphoma, which can decrease the possibility of misdiagnosis.
Keywords: p63; diffuse large B-cell lymphoma; lymphoma; case report