糖原合酶激酶-3β：神经炎症的潜在重要调节靶点
| 作者: |
1胡胜,
2田绍文,
1,3游咏
1 南华大学附属第一医院神经内科，湖南 衡阳 421001 2 桂林医学院基础医学院，广西 桂林 541000 3 海南医学院第二附属医院神经内科，海口 570100 |
| 通讯: |
游咏
Email: 652797262@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.04.023 |
| 基金: | 国家自然科学基金(81771170)；湖南省自然科学基金(2018JJ2359)；湖南省自然科学基金青年基金(2019JJ0551)。 |
摘要
中枢神经系统的炎症反应在神经退行疾病、精神疾病等中起重要作用，其涉及到胶质细胞的激活、炎症因子的释放等，其炎症反应涉及许多信号调节通路，但具体仍需深入研究。目前越来越多的研究证据表明糖原合酶激酶-3β(glycogen synthase kinase-3β，GSK-3β)参与了神经炎症反应的多条调控途径，包括内质网应激、线粒体损伤等，其激活状态可增强与炎症反应调控相关信号促进神经炎症反应导致中枢神经系统损伤。
关键词：
神经炎症；糖原合酶激酶-3β；Toll样受体；内质网应激；线粒体
Glycogen synthase kinase-3β: A potentially important regulatory target for neuroinflammation
CorrespondingAuthor: YOU Yong Email: 652797262@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.04.023
Foundation: This work was supported by the National Natural Science Foundation (81771170), the Natural Science Foundation of Hunan Province (2018JJ2359), and the Youth Foundation Project of Natural Science Foundation of Hunan Province (2019JJ0551), China.
Abstract
The inflammatory response of the central nervous system plays an important role on neurodegenerative diseases and mental diseases etc, involving the activation of gliocyte and the release of inflammatory factors and many other signaling regulatory pathways. However, more of this inflammatory response needs to be further studied. Nowadays, more and more reserches has confirmed that glycogen synthase kinase-3β (GSK-3β) takes part in regulating pass ways of neuroinflammation, including Endoplasmic reticulum stress and mitochondrial damage. Activated GSK-3β can strengthen signal of inflammation to promote neuroinflammatory reaction that leads to the damage of central nervous system. Hence, this article gives a brief introduction that GSK-3β regulates and controls related mechanism of neuroinflammation. Meanwhile, the paper discusses the prospect of GSK-3β for researches about diseases related with neuroinflammation.
Keywords：
neuroinflammation; glycogen synthase kinase-3β; Toll-like receptor; endoplasmic reticulum stress; mitochondria