TRIM家族在宫颈癌中的研究进展
| 作者: |
1蔡园杰,
1万晓琪,
1王艳
1 哈尔滨医科大学附属第一医院妇科一科，哈尔滨 150001 |
| 通讯: |
王艳
Email: docwyan@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.01.032 |
摘要
宫颈癌是女性中常见恶性肿瘤之一，病死率较高，全球死亡女性超过88%发生在发展中国家，其中以宫颈鳞癌最为常见。三方基序蛋白(tripartite motif-containing protein，TRIM)家族大多数具有E3泛素连接酶活性，且与多种生理过程有关，包括细胞增殖、DNA修复、信号转导和转录。近年大量研究发现TRIM家族通过多种通路参与宫颈癌的发生和发展。
关键词：
TRIM家族；宫颈癌；泛素化；信号通路
Research progress of TRIM family in cervical cancer
CorrespondingAuthor: WANG Yan Email: docwyan@163.com
DOI: 10.3978/j.issn.2095-6959.2022.01.032
Abstract
Cervical cancer is one of the common malignant tumors among women, with a high mortality rate. More than 88% of the global female deaths occur in developing countries, among which the cancer caused by cervical squamous cell carcinoma is the most common. Most of the tripartite motif-containing protein (TRIM) families possess E3 ubiquitin ligase activity and are involved in a variety of physiological processes, including cell proliferation, DNA repair, signal transduction, and transcription. In recent years, a large number of studies have found that the TRIM family participates in the occurrence and development of cervical cancer through a variety of pathways.
Keywords：
TRIM family; cervical cancer; ubiquitination; signaling pathway