桥本甲状腺炎相关抗体与甲状腺乳头状癌的关系研究进展
| 作者: |
1于博,
1赵文君,
1王慧芳,
2王瑞佳,
3刘静
1 山西医科大学第一临床医学院甲状腺外科，太原 030001 2 山西省人民医院胃肠胰及腹壁与疝外科，太原 030012 3 山西医科大学第一医院甲状腺外科，太原 030001 |
| 通讯: |
刘静
Email: liujing5585@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.09.031 |
| 基金: | 山西省社会发展基金(201903D321147)。 |
摘要
在过去的30年中，随着影像学技术的发展及人们保健意识的提升，甲状腺癌(thyroid carcinoma，TC)的检出率明显上升，TC成为常见的恶性肿瘤之一，其中又以甲状腺乳头状癌(papillary thyroid carcinoma，PTC)发病率最高，因其分化程度高，恶性程度低，预后明显优于其他系统恶性肿瘤。桥本甲状腺炎(Hashimoto thyroiditis，HT)是一种常见的甲状腺自身免疫性疾病，其患者血清中可检出抗甲状腺过氧化物酶抗体(antithyroid peroxidase antibody，TPOAb)和抗甲状腺球蛋白抗体(antithyroglobulin antibody，TgAb)等多种自身免疫性抗体。近年来，HT合并TC的发病率呈上升趋势，两者之间的相关性成为临床研究的热点。有研究提出HT相关抗体状态与PTC的发生及病情进展密切相关。明确两者间的联系并将其运用于临床工作中显得尤为重要。
关键词：
甲状腺癌；甲状腺乳头状癌；桥本甲状腺炎；抗甲状腺球蛋白抗体；抗甲状腺过氧化物酶抗体
Research progress of the connection between Hashimoto thyroiditis-related antibodies and papillary thyroid carcinoma
CorrespondingAuthor: LIU Jing Email: liujing5585@163.com
DOI: 10.3978/j.issn.2095-6959.2021.09.031
Foundation: This work was supported by Shanxi Provincial Social Development Fund, China (201903D321147).
Abstract
In the past 30 years, with the development of imaging technology and the improvement of people’s health awareness, the detection rate of thyroid carcinoma (TC) has increased markedly. Thyroid cancer has become one of the common malignant tumors, among which the incidence of papillary thyroid carcinoma (PTC) is the highest. Because of its high degree of differentiation and low malignancy, its prognosis is significantly better than other systemic malignancies. Hashimoto thyroiditis (HT) is a common autoimmune disease of the thyroid, and various autoimmune antibodies such as antithyroid peroxidase antibody (TPOAb) and antithyroglobulin antibody (TgAb) can be detected in the serum of patients. In recent years, the incidence of HT with thyroid cancer has been rising, so the correlation between them has become a hot spot in clinical research. Studies have suggested that the related antibodies of HT is closely related to the occurrence and progression of PTC. It is particularly important to clarify the connection between them and apply it in clinical work.
Keywords：
thyroid carcinoma; papillary thyroid carcinoma; hashimoto thyroiditis; antithyroglobulin antibody; antithyroid peroxidase antibody