文章摘要

结直肠癌骨转移机制的研究进展

作者: 1许建发, 1冯和林, 2檀紫瑞, 3苏明明, 4王贵英
1 河北医科大学第四医院骨科，石家庄 050011
2 河北医科大学第四医院胸外科，石家庄 050011
3 河北医科大学第四医院外科，石家庄 050011
4 河北医科大学第三医院外科，石家庄 050051
通讯: 王贵英 Email: tizq12@vip.163.com
DOI: 10.3978/j.issn.2095-6959.2021.10.028
基金: 河北省青年科技课题(20201081)。

摘要

通过回顾性复习已发表的文献探讨结直肠癌骨转移的分子机制。近年来，结直肠癌骨转移的发病率逐年增高，并呈快速增长趋势。而且，许多有关结直肠癌骨转移的研究揭示了结肠癌骨转移的发生与肿瘤细胞本身、骨微环境以及二者的相互作用密切相关。目前，结直肠癌骨转移的具体机制尚不明确。本文通过回顾近年来国内外文献的报道，从结直肠癌骨转移的一般规律、骨转移途径以及细胞分子机制多个方面对结直肠癌骨转移的机制进行总结，从而加深了解结直肠癌骨转移自然病程，探究其存在的不同的临床和生物学行为模式，进行先进的分子和遗传学研究，以期寻找特定的肿瘤表达特征，从而为研制新的分子靶向药物提供新靶点，改善结直肠癌骨转移患者的预后。
关键词： 结直肠癌；骨转移；机制

Progress in bone metastasis mechanism of colorectal cancer

Authors: 1XU Jianfa, 1FENG Helin, 2TAN Zirui, 3SU Mingming, 4WANG Guiying
1 Department of Orthopedics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
2 Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
3 Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
4 Department of Surgery, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

CorrespondingAuthor: WANG Guiying Email: tizq12@vip.163.com

DOI: 10.3978/j.issn.2095-6959.2021.10.028

Foundation: This work was supported by Hebei Provincial Youth Science and Technology Project, China (20201081).

Abstract

The molecular mechanism of bone metastasis in colorectal cancer was discussed by literature review. The incidence of colorectal cancer bone metastasis has been increasing year by year, and has shown a rapid growth trend. Moreover, many studies on bone metastasis of colorectal cancer have revealed that the occurrence of bone metastasis of colorectal cancer is closely related to tumor cells, bone microenvironment and their interaction. Currently, the specific mechanism of colorectal cancer bone metastasis is not clear. This article summarizes the mechanism of colorectal cancer bone metastasis from the general law, bone metastasis pathway and cellular and molecular mechanism by reviewing the reports of domestic and foreign literature in recent years. The purpose is to deepen the understanding of the natural course of colorectal cancer bone metastasis, explore its different clinical and biological behavior patterns, and carry out advanced molecular and genetic research. In order to find specific tumor expression characteristics, so as to provide new targets for us to develop new molecular targeted drugs and improve the prognosis of patients with bone metastasis of colorectal cancer.
Keywords： colorectal cancer; bone metastasis; mechanism

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