Objective: To explore the effect of cognitive behavior intervention on preoperative anxiety, preoperative hope level and postoperative physical recovery of patients with chronic cholecystitis after minimally invasive cholecystectomy. Methods: From March 2016 to September 2018, 108 patients with chronic cholecystitis who received minimally invasive cholecystectomy in our hospital were divided into a control group and an intervention group by random number table method, 54 cases in each group. The patients in the control group received routine intervention before operation, and the patients in the intervention group received cognitive behavioral intervention on the basis of routine intervention. Self-rating Anxiety Scale (SAS) and Hertz Hope Index (HHI) were used to measure the anxiety score and hope level score of the two groups immediately after admission, and 12 hours before operation. In addition, the physical recovery time after operation was recorded. Results: Immediately after admission, there was no significant difference in SAS score, HHI total score and scores of all dimensions between the two groups (P>0.05). Twelve hours before operation, the SAS score of the intervention group was lower than that of preoperative and control group (P<0.05), and the total score of HHI and the scores of all dimensions were higher than those of preoperative and control group (P<0.05). The patients in the intervention group had shorter bowel exhaust time, activity time after operation and hospital stay after operation than those in the control group (P<0.05). Conclusion: The cognitive behavioral intervention can effectively relieve the anxiety before operation, increase the level of hope, and accelerate the physical recovery after operation.