Objective: To explore the intervention effect of early language rehabilitation nursing combined with hand training on language movement in stroke patients with aphasia. Methods: A total of 110 patients with aphasia after stroke who were hospitalized in the Department of Neurology of our hospital from January 2018 to December 2019 were selected as the study objects. They were divided into a control group and a combined group according to simple random grouping method (55 cases in each group). The control group was given early language rehabilitation routine nursing, while the combined group was combined with hand training on the basis of the control group, all of which were continuously observed for 4 weeks. Chinese Aphasia Checklist and Boston Aphasia Diagnostic Examination (BDAE) were used to evaluate the rehabilitation effect of the language function in the two groups, and Chinese version of Stroke Aphasia Quality of Life Scale (SAQOL-39g) was used to evaluate the quality of life of the two groups before and after intervention. Results: The scores and total scores of oral expression, listening comprehension, and reading ability in the combined group were higher than those before the intervention (P<0.05), and significantly higher than those in the control group (P<0.05). The total effective rate of rehabilitation in the combined group after 4 weeks was 94.55%, which was significantly higher than that in the control group (81.82%, P<0.05). The scores and total scores of SAQOL-39g in the combined group were significantly higher than those in the control group (P<0.05). Conclusion: Early language rehabilitation nursing combined with hand training can effectively promote the recovery of language function in stroke patients with aphasia, improve the total effective rate of language rehabilitation and the quality of life.