Objective: To investigate the application effect of follow-up nursing management measures guided by WeChat platform on peritoneal dialysis at home in patients with uremia, and to provide relevant guidance for the follow-up nursing management of patients. Methods: A total of 98 uremic patients who were at home for peritoneal dialysis after diascharging from the First Affiliated Hospital of Hainan Medical College from January 2018 to January 2019 were included as the research subjects. According to the random odd-even number method, they were divided into a control group and an intervention group, with 49 cases in each group. Patients in the control group were treated with traditional follow-up nursing management measures, and patients in the intervention group were treated with follow-up nursing management guided by WeChat platform. After follow-up for 6 months to 1 year, the peritoneal equilibration test (PET), urea clearance index (Kt/V), creatinine clearance rate (Ccr), blood calcium, blood phosphorus, anemia and other indicators were compared before and after follow-up in the two groups, and the incidence of complications such as peritonitis, drift tube and patients’ satisfaction with nursing were analyzed in the two groups. Results: There was no significant difference in dialysis adequacy rate, Kt/V and Ccr between the two groups before follow-up (P>0.05). After 0.5 to 1 year of follow-up, the dialysis adequacy rate, Kt/V and Ccr in the intervention group were significantly higher than those in the control group, and the dialysis sufficiency rate, Kt/V, Ccr in the intervention group were significantly higher than those before the follow-up, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the comparison of serum calcium, serum phosphorus and anemia levels between the two groups before follow-up (P>0.05). After 0.5 to 1 year of follow-up. The blood calcium and Hb levels of the intervention group were significantly higher than those of the control group, but blood phosphorus level was significantly lower than those of the control group, and the blood calcium and Hb levels of the intervention group were significantly higher than those before the follow-up, and the blood phosphorus level was significantly lower than that before the follow-up. The aforementioned differences were statistically significant (P<0.05). The incidence of complications of peritonitis and drifting tube in the intervention group was 10.20%, which was significantly lower than 28.57% of the control group, and the difference was statistically significant (P<0.05). The satisfaction of patients in the intervention group with follow-up care was 97.96%, which was significantly higher than 75.51% of the control group, and the difference was statistically significant (P<0.05). Conclusion: The follow-up nursing management guided by the WeChat platform has a significant effect on the peritoneal dialysis of patients with uremia at home. It is worth to be popularized in that it can promote the effective improvement of the dialysis adequacy of patients, significantly propel the levels of blood calcium, anemia and other indicators, reduce the level of blood phosphorus, and effectively decrease the incidence of peritonitis, drifting tube and other complications.