白细胞介素在银屑病自噬和细胞焦亡中的研究进展
| 作者: |
1王悦琪,
1周婧
1 哈尔滨医科大学附属第二医院皮肤病与性病科，哈尔滨 150000 |
| 通讯: |
周婧
Email: zhoujing782013@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.09.030 |
| 基金: | 国家自然科学基金(81602753)。 |
摘要
银屑病病因不明。它是一种在多基因遗传背景下的系统疾病的皮肤表现，可由环境、情绪等多种因素共同作用导致发病。多种病因假说支持银屑病的发病机制，其中有关遗传及免疫因素参与发病是更加令人信服的，包括各种免疫细胞和细胞因子等多种因素都参与了银屑病发病机制。几种与银屑病相关的白细胞介素(interleukin，IL)在细胞焦亡和自噬中起重要作用。
关键词：
银屑病；白细胞介素；自噬；细胞焦亡
Research progress of interleukin in autophagy and pyroptosis of psoriasis
CorrespondingAuthor: ZHOU Jing Email: zhoujing782013@126.com
DOI: 10.3978/j.issn.2095-6959.2021.09.030
Foundation: This work was supported by the National Natural Science Foundation, China (81602753).
Abstract
The etiology of psoriasis is unknown. Psoriasis is a skin manifestation of systemic diseases under the background of polygenetic inheritance, which can be caused by environment, emotion, and other factors. A variety of etiological hypotheses support the pathogenesis of psoriasis, but the involvement of genetic and immune factors in the pathogenesis of psoriasis is more convincing, including a variety of immune cells, cytokines and other factors involved in the pathogenesis of psoriasis. Several kinds of psoriatic-related interleukin play an important role in pyroptosis and autophagy.
Keywords：
psoriasis; interleukin; autophagy; pyroptosis