乳酸/HCAR1信号系统的生物学功能研究进展
作者: |
1帅念念,
1周佳秀,
2田绍文,
1王波,
1,3旷昕
1 南华大学附属第一医院麻醉科,湖南 衡阳 421001 2 桂林医学院基础医学院广西脑与认知神经科学重点实验室,广西 桂林 541001 3 南方医科大学附属龙华区人民医院麻醉科,广东 深圳 518109 |
通讯: |
旷昕
Email: kx6924@126.com |
DOI: | 10.3978/j.issn.2095-6959.2021.08.032 |
基金: | 湖南省自然科学基金(2018JJ3465)。 |
摘要
羟基羧酸受体1(hydroxy-carboxylic acid receptor 1,HCAR1)是一种孤儿G蛋白耦联受体,也是乳酸的特异性受体,广泛分布于中枢和外周组织。近年来,越来越多的研究表明,乳酸/HCAR1信号系统在机体发挥重要作用。乳酸/HCAR1信号系统通过激活下游信号通路,参与内分泌系统、心血管系统、神经系统、免疫系统、肿瘤等相关系统疾病的发生和发展过程。
关键词:
乳酸;羟基羧酸受体1;GPR81;内分泌系统;神经系统;肿瘤
Research progress in the biological function of lactate/HCAR1 signaling system
CorrespondingAuthor: KUANG Xin Email: kx6924@126.com
DOI: 10.3978/j.issn.2095-6959.2021.08.032
Foundation: This work was supported by the Hunan Provincial Natural Science Foundation, China (2018JJ3465).
Abstract
Hydroxy-carboxylic acid receptor 1 (HCAR1) is an orphan G protein-coupled receptor and a specific receptor for lactate, which is widely distributed in central and peripheral tissues. In recent years, more and more studies have shown that lactate/HCAR1 signaling system plays an important role in the body. By activating the downstream signaling pathway, the lactate/HCAR1 signaling system is involved in the occurrence and development of diseases related to endocrine system, cardiovascular system, nervous system, immune system, tumors, etc.
Keywords:
lactate; hydroxy-carboxylic acid receptor 1; GPR81; endocrine system; nervous system; tumors