文章摘要

腹膜透析患者幽门螺杆菌感染及其对微炎症、营养状态的影响

作者: 1赵云侠, 2陈文
1 万宁市人民医院内一科,海南 万宁 571500
2 海南医学院第二附属医院肾内科,海口 570311
通讯: 陈文 Email: 13907685889@163.com
DOI: 10.3978/j.issn.2095-6959.2021.03.006

摘要

目的:调查腹膜透析(peritoneal dialysis,PD)患者幽门螺杆菌(Helicobacter pylori,Hp)感染情况,以及Hp感染对患者微炎症状态和营养状态的影响。方法:选择万宁市人民医院肾内科于2016年1月至2020年1月期间收治的178例持续性非卧床PD患者为研究对象。行14C尿素呼气试验(14C-urea breath test,14C-UBT)检查以确定是否存在Hp感染,测定血清C反应蛋白(C-reactive protein,CRP)以及白蛋白(albumin,ALB),前白蛋白(prealbumin,PAB)浓度。比较Hp阳性及阴性者上述指标的差异,以及Hp阳性者抗Hp治疗前后上述指标的变化。结果:PD患者Hp感染发生率为41.57%;Hp阳性组患者的血清CRP水平明显高于Hp阴性组,而血清Alb,PAB水平明显低于Hp阴性组,差异均有统计学意义(均P<0.05);Hp阳性患者抗Hp治疗后,患者的血清CRP水平较治疗前明显降低,血清Alb、PAB水平明显升高,差异均有统计学意义(均P<0.05)。结论:PD患者Hp感染会加重患者的微炎症状态和营养不良,抗Hp治疗对改善微炎症状态和营养不良有利。
关键词: 腹膜透析;幽门螺杆菌;微炎症;营养不良;并发症

Helicobacter pylori infection in peritoneal dialysis patients and its effect on microinflammation and nutritional status

Authors: 1Yunxia ZHAO, 2Wen CHEN
1 The First Department of Internal Medicine, Wanning People's Hospital, Wanning Hainan 571500, China
2 Department of Nephrology, Second Affiliated Hospital of Hainan Medical College, Haikou 570311, China

CorrespondingAuthor: Wen CHEN Email: 13907685889@163.com

Abstract

Objective: To investigate the infection of Helicobacter pylori (Hp) in peritoneal dialysis (PD) patients and the effect of Hp infection on their microinflammation and nutritional status. Methods: A total of 178 patients with continuous ambulatory PD admitted to Wanning People's Hospital from January 2016 to January 2020 were selected as the research objects. 14C-UBT was performed to determine the presence of Hp infection. The levels of C-reactive protei (CRP), albumin (ALB) and prealbumin (PAB) in serum were measured. The differences of the above indexes between Hp-positive and Hp-negative patients and the changes of the above indexes before and after anti-Hp treatment were compared. Results: The incidence of Hp infection in PD patients was 41.57%. The serum CRP level in the Hp-positive group was significantly higher than those in the Hp-negative group, while the serum Alb and PAB levels were significantly lower than those in the Hp-negative group, the difference was statistically significant (P<0.05). The serum CRP level in Hp-positive patients after anti-Hp treatment was significantly lower than those before the treatment, and the serum Alb and PAB levels were significantly higher than those before treatment. The difference was statistically significant (P<0.05). Conclusion: Hp infection in peritoneal dialysis patients can aggravate the microinflammatory state and malnutrition, and Hp eradication therapy is beneficial in improving both symptoms.
Keywords: peritoneal dialysis; Helicobacter pylori; microinflammation; malnutrition; complications