Objective: To investigate the effect of LERANS mode in the health education for patients with coronary heart disease after stent implantation, and to provide relevant guidance for clinical care of patients. Methods: A total of 156 cases of patients who underwent coronary heart disease stent implantation in our hospital from October 2017 to October 2018 were selected as the research subjects. All subjects were divided into control group and study group according to the random odd and even number method, with 78 cases in each. Patients in the control group were given the conventional health education model, and patients in the study group were given the LERANS mode. The self-care ability and self-efficacy of the two groups of patients were compared before and after education, and the quality of life of the two groups of patients were analyzed. Results: After education, the self-care ability of the two groups of patients was significantly improved, the total score of the self-care ability of the study group was (149.82±24.12) points, which was significantly higher than that of the control group (121.03±21.15), the difference was statistically significant (P<0.05); after education, the self-efficacy of the two groups of patients was significantly improved, the self-efficacy score of the study group was (35.84±6.33) points, which was significantly higher than that of the control group (25.25±5.14) points, the difference was statistically significant (P<0.05); the total quality of life score of patients in the study group was (402.43±98.61) points, which was significantly higher than that of the control group (328.12±71.57) points, the difference was statistically significant (P<0.05). Conclusion: The LERANS mode has a significant effect on the health education of patients with coronary heart disease after stent implantation, and promotes the patient’s self-care ability and self-efficacy, thereby improving their quality of life, which is worth promoting vigorously.