Objective: To explore the intervention effect of predictive nursing based on the transformation of motivational behavior on patients with mania, and provide guidance for patient care. Methods: A total of 100 patients with mania treated in our hospital from March 2017 to March 2019 were selected as the research subjects. According to the random number table method, they were divided into observation group and control group (50 cases for each). Patients in the control group were given routine nursing measures, and the observation group was given predictive nursing based on motivational behavior conversion based on the nursing measures in the control group. Before and after nursing, the general assessment scale (GAS) and mania scale (BRMS) were used to evaluate the nursing effect of the two groups of patients, and the mental status check (PSE) and social function defect screening (SDSS) were used to evaluate the patient's labor capacity; patients in the group received treatment compliance, seizure probability, length of hospital stay, hospitalization cost, time of medication, and nursing satisfaction. Results: Before nursing, there was no significant difference in GAS and BRMS scores between the two groups of patients (P>0.05); after nursing, the GAS scores in the observation group were significantly higher than the control group, and the BRMS scores were lower than the control group (P<0.05). After nursing, the proportion of patients with disability in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The length of stay in the observation group, medication time, compliance with treatment, cost of hospitalization, and probability of manic in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: The predictive nursing mode based on the transformation of motivational behavior has significant nursing effect, which is beneficial to improve the compliance of mania patients in compliance with medical treatment, shorten the length of hospitalization, promote patient recovery, and prevent the occurrence of aggressive behavior in patients.