Objective: To observe the therapeutic effect of constant temperature oxygen ultrasound atomization combined with meibomian gland dredging in the treatment of meibomian gland dysfunction (MGD) related dry eye, so as to provide theoretical basis for physical treatment and nursing of MGD related dry eye patients. Methods: A total of 119 cases of MGD related dry eye were randomly divided into an intervention group (60 cases) and a control group (59 cases). The control group was given routine treatment, that is, hot compress, sodium hyaluronate eye liquid and Dianbishu eye ointment. On this basis, the patients in the intervention group were treated with local constant temperature oxygen ultrasonic atomization combined with meibomian gland dredging. Before and 3 months after the intervention, the intervention effects of the two groups were compared by Dry Eye Questionnaire (DEQ) score, Ocular Surface Disease Index (OSDI) score, tear break-up time (BUT), length of tear secretion, lipid layer thickness and meibomian gland grading examination. Results: Compared with the control group, the intervention group had more advantages in the length of tear secretion (Schirmer I test), but, the thickness of tear lipid layer, the score of meibomian gland and the patients' conscious symptoms. Conclusion: Meibomian gland dredging combined with local constant temperature oxygen ultrasonic atomization is effective in the treatment of MGD related dry eye, which is beneficial to relieve dry eye symptoms, improve eye comfort, promote tear film recovery, and ultimately improve the quality of life of patients.