Objective: To evaluate the feasibility of modified tissue adhesive injection in the treatment of gastric varices. Methods: Sixty patients with gastric variceal bleeding admitted to the Department of Gastroenterology of Xinqiao Hospital from January 2018 to December 2019 were studied. Overall, 30 patients underwent traditional endoscopic injection (the traditional injection group), and 30 patients underwent a new method of modified tissue adhesive injection (the new injection method group). The operability of two injection methods in operation were compared. Results: There was no statistically significant difference in clinical basic information between the 2 groups. The new injection method group had shorter operation time, lower needle blocking rate and less intraoperative blood loss than the traditional injection method, and the difference was statistically significant (P<0.01). There was no statistically significant difference between the 2 groups in the success rate of hemostasis and the rate of rebleeding (P>0.05). Conclusion: Although there is no difference in the therapeutic effect between the 2 groups, the new injection method is more convenient and faster for operation with high safety, simple steps and strong operability, and is worthy of clinical reference and trial.