Objective: To explore effects of structural psychological intervention combined with individualized health education on psychological status, self-efficacy and health behavior of patients with acute pancreatitis (AP). Methods: Sixty AP patients who were admitted to Affiliated Hospital of Southwest Medical University were enrolled. They were divided into a control group (n=30) and an observation group (n=30) according to even-odd order of admission. The control group was given routine nursing intervention, while the observation group was given structural psychological intervention combined with individualized health education intervention. The psychological status [Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD)], scores of self-efficacy and health behavior, and patient satisfaction were compared between the two groups. Results: After the intervention, HAMA and HAMD scores of the observation group were significantly lower than those of the control group (P<0.05). After the intervention, scores of communication, physiological symptom response, psychological symptom response, and treatment compliance in the observation group were significantly higher than those in the control group (P<0.05); scores of health responsibility, physical symptom response, exercise and training, nutrition, self-realization, interpersonal relationship, and stress response in the observation group were significantly higher than those in the control group (P<0.05); scores of service attitude, service content and personnel quality, and total score in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Structural psychological intervention combined with individualized health education can reduce negative emotion of AP patients, improve self-efficacy, health behavior and satisfaction.