Objective: To explore the effect of self-report outcome system in strabismus children. Methods: From February 2018 to August 2019 in First Affiliated Hospital, Army Medical University, children with strabismus were recruited and assigned into an intervention group and a control group with 65 cases in each group. Children in the experimental group received dynamic multidimensional intervention based on self-report outcome system after operation, while the control group received routine follow-up visits, telephone follow-up and counseling guidance. Patient-Report Outcomes (PRO), Child Intermittent Exotropia Questionnaire (Child-IXTQ), Hospital Anxiety and Depression Scale (HAD) were used to evaluate before and after 6-month intevention. Infrequency of complications, quality of life, anxiety and depression scale were compared between the 2 groups. Results: The frequency of main symptoms (diplopia, eye fatigue and pain) threshold events in the experimental group was significantly lower than that in the control group (P<0.05); the intervention quality of life score in the experimental group (76.54±9.73) was significantly higher than that in the control group (68.64 ± 10.23); the anxiety score in the experimental group was (4.32±1.21), which was significantly lower than that in the control group (6.98 ± 0.64); the depression score of the experimental group (5.66±1.07) was significantly lower than that in the control group (6.53±1.44), the difference was statistically significant (P<0.05). Conclusion: Implementation of strabismus self-report outcome system among strabismus children can dynamic monitoring of the symptoms and quality of life, which can not only reduce the frequency of symptom threshold events, but also reduce negative emotions such as anxiety and depression, thus improving the quality of life of strabismus patients.