血浆D-二聚体、纤维蛋白原含量、AT-III活性的测定在恶性肿瘤诊断中的临床价值
| 作者: |
1金萍,
1王亚萍,
2孙兵,
1龚芳,
1卢志贤
1 江南大学附属医院检验科，江苏 无锡 214041 2 中国人民解放军63680部队医院检验科，江苏 江阴 214400 |
| 通讯: |
卢志贤
Email: seed001lzx@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.10.005 |
| 基金: | 江苏省“333”人才资助项目(BRA2019152)。 |
摘要
目的：检测不同恶性肿瘤患者血浆D-二聚体(D-dimer，D-D)和纤维蛋白原(fibrinogen，Fbg)含量及抗凝血酶III(antithrombin III，AT-III)活性，探讨其对于恶性肿瘤患者诊断的临床价值。方法：由法国STAGO公司的全自动凝血分析仪测定265例恶性肿瘤患者血浆D-D，AT-III活性，Fbg含量并进行比较，同时选择100例健康体检者作为正常对照组。结果：恶性肿瘤患者血浆D-D和Fbg含量升高，与正常对照组比较差异有统计学意义(P<0.05)，AT-III活性显著低于正常对照组(P<0.05)。结论：通过检测患者D-D，AT-III活性，Fbg含量有助于恶性肿瘤的辅助诊断，具有临床应用价值。
关键词：
恶性肿瘤；D-二聚体；抗凝血酶III活性；纤维蛋白原含量
Clinical value of plasma D-dimer, fibrinogen content, and AT-III activity in diagnosis of malignant tumor
CorrespondingAuthor: LU Zhixian Email: seed001lzx@163.com
DOI: 10.3978/j.issn.2095-6959.2020.10.005
Foundation: This work was supported by the ‘333’talent funding project of Jiangsu Province, China (BRA2019152).
Abstract
Objective: To investigate the clinical value of plasma D-dimer, fibrinogen, and antithrombin III activity in patients with malignant tumor. Methods: The densities of plasma D-dimer, antithrombin III activity, fibrinogen were detected in the 265 patients with malignant tumors. And 100 healthy cases were selected as a normal control group. The detecting instrument was Automatic Coagulation Analyzer of STAGO company (France). Results: Compared with the normal control group, the levels of plasma D-dimer and fibrinogen in patients with malignant tumors were significantly increased (P<0.05), antithrombin III activity was significantly lower than that of the normal control group (P<0.05). Conclusion: The detection of D-dimer, antithrombin III activity, and fibrinogen is helpful for the auxiliary diagnosis of malignant tumor.
Keywords：
malignant tumor; D-dimmer; antithrombin III activity; fibrinogen