Objective: To systematically assess the effect of modified electroconvulsive therapy (MECT) plus antipsychotics (APs) on memory in patients with schizophrenia, even the relationship between the effect with time. This study aimed to provide meaningful reference for clinical treatment. Methods: Random controlled trials (RCTs) measuring the effect of MECT plus APs on memory function in schizophrenic patients were searched. Quality of the included literature was evaluated and reviewed, and the data extracted were meta-analyzed. Results: 1) 14 RCTs (n=1,394 patients) were included in study, 702 patients in the MECT plus APs group and 692 patients in APs group. 2) Main results: comparing the Wechsler memory scale score after different treatments, it was found that Memory Quotient (MQ) in MECT plus APs group was lower than in APs group on the first day of treatment with statistically significant differences. There was no significant difference in MQ between the two groups at 1st, 4th and 8th week of treatment and at 2nd, 8th week after treatment. 3) Secondary results: at the end of treatment, the scores of Picture Recognition, Picture Recall, Association and Figure Recognition were lower in MECT plus APs group (n≤12 times) than in APs group with statistically significant differences. But there was no significant difference between the MECT plus APs group (n>12 times) and APs group. Conclusion: MECT plus APs treatment was found to be more significant but temporary impairment than APs treatment on memory in schizophrenic patients. As the course of MECT increased, the impairment would gradually mitigate after 1st week of treatment. Increasing MECT course (n>12 times) would reduce the impairment on short-term memory and instantaneous memory in patients with schizophrenia.