Homeobox (Hox) genes are highly conserved at the genomic level and have been well-described as important players in regulation of numerous processes including apoptosis, receptor signaling, differentiation, motility, angiogenesis, and metastasis. HoxC10, as a member of the Hox family of genes, was significantly correlated with the occurrence, metastasis, and prognosis of numerous malignancies such as oral squamous cell carcinoma, cervical cancer, thyroid cancer, pancreatic cancer, colorectal cancer, and lung cancer. Gastric cancer is one of the most common malignant tumors in the world. Recently reported, aberrations in HoxC10 expression was implicated in the proliferation, apoptosis, invasion and metastasis of cancer cells, which was related to the MAPK pathway, NF-κB pathway, and upregulating proinflammatory cytokines. Future researches need to be further clarified the specific mechanism of HoxC10 in the pathogenesis of gastric cancer and their clinical significance, which may provide new targets for gastric cancer treatment.