滤泡辅助性T细胞参与结缔组织病的发病机制
| 作者: |
1惠晓艳,
1朱克强,
1王晨,
2许超
1 南京中医药大学第三临床医学院，南京 210023 2 南京中医药大学附属中西医结合医院风湿免疫科，南京 210028 |
| 通讯: |
许超
Email: chao1030@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.01.028 |
| 基金: | 江苏省中医药局课题(YB201927)；南京市科技计划项目(201715069)。 |
摘要
滤泡辅助性T(T follicular helper，Tfh)细胞是CD4+T淋巴细胞的一个子集，定位于淋巴滤泡，具有辅助B细胞的功能。它参与生发中心(germinal center，GC)的形成和B细胞的发育并调控其功能。Tfh细胞发育和功能障碍可导致免疫系统紊乱，引起多种结缔组织病发生。明确Tfh细胞参与结缔组织病的发病机制，可更加全面地认识结缔组织病，为该病种提供靶向Tfh细胞治疗的新途径。
关键词：
滤泡辅助性T细胞；结缔组织病；自身免疫性疾病
Follicular helper T cells involved in the pathogenesis of connective tissue diseases
CorrespondingAuthor: XU Chao Email: chao1030@126.com
DOI: 10.3978/j.issn.2095-6959.2021.01.028
Foundation: This work was supported by the Project of Jiangsu Provincial Traditional Chinese Medicine Bureau (YB201927) and Nanjing Science and Technology Plan Project (201715069), China
Abstract
Follicular helper T (Tfh) cells are a subset of CD4+ T lymphocytes that are localized to lymphoid follicles and have the function of helping B cells. It participates in the formation of the germinal center (GC) and the development of B cells and regulates their function. Tfh cell development and dysfunction can lead to immune system disorders, causing a variety of connective tissue diseases. Studying the involvement of Tfh cells in the pathogenesis of connective tissue disease contributes to a more comprehensive understanding of connective tissue disease and provides a new way to Tfh cell targeted therapy.
Keywords：
follicular helper T cells; connective tissue disease; autoimmune disease