Objective: To study and analyze the clinical symptoms improvement value of fine nursing and humanistic care in acupoint application of high-pressure patients. Methods: A total of 150 patients with hypertension who were admitted to our hospital from October 2018 to November 2019 were treated by acupoint application. After entering the patient data into the computer, the patients were randomly divided into the conventional group (75 cases, routine high blood pressure treatment and Nursing) and the research group (75 cases), and the patients were given meticulous care and humanistic care. The blood pressure, Self-rating Anxiety Scale (SAS), Self-rating Depression Scale, SCL-90 and the satisfaction of this nursing were compared between the two groups. Results: After nursing, the systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the patients in the study group were lower than those in the conventional group. The physical function, emotional function, and social function of SAS, SDS and SCL-90 were better than those in the conventional group. At the same time, the patients in the study group were more satisfied with the final nursing results, with satisfaction of 96%, higher than that of the conventional group (82.67%) The difference was significant (P<0.05). Conclusion: The application of fine nursing and humanistic care in the acupoint application of hypertension patients can further improve the treatment effect, stabilize the patients' bad mood, improve their quality of life, and make the patients more satisfied with the final treatment effect.