Objective: To explore the effect of sequential multimodal analgesia on the analgesic effect, cost, recovery index and complications of functional neck lymphadenectomy for thyroid cancer. Methods: A total of 88 patients who underwent functional neck lymphadenectomy for thyroid cancer were included. Random number table was used to divide them into sequential multimodal analgesia group (D group) and traditional single-modal analgesia group (T group), with 44 patients in each group. In group D, 40 mg of parecoxib hydrochloride was given for preemptive analgesia during anesthesia induction; before intubation, 2 mL of 1% Dyclonine glue to 1/3 of the front end of the tracheal tube was applied; before operation, bilateral superficial cervical plexus block was conducted under the guidance of B-ultrasound. Before suturing the incision, the surgeon placed a 22G intravenous indwelling trocar at the nerve point of the superficial cervical plexus under direct vision below the posterior edge of the midpoint of the sternocleidomastoid muscle on the affected side. After the incision was sutured on the opposite side, a trocar was inserted under the guidance of ultrasound, and a local anesthetic was added. 6 hours after the operation, another local anesthetic was added through the indwelling cannula embedded in the superficial cervical plexus and the trocar was removed. Oral administration of paracetamol and oxycodone tablets was started 12 hours after the operation. In group T, there was no preemptive analgesia, the incision was sutured directly, and PCIA was used for intravenous analgesia (dazocine 40 mg + sufentanil 50 μg + tropisetron 4 mg) after surgery. At 1, 6, 12 and 24 hours after operation, visual analog scale VAS was used to evaluate the analgesic effect of the two groups; the serum IL-6 concentration before and 24 hours after operation was measured; the total amount of remifentanil during operation, the first time to get out of bed, the first time to eat fluid, the length of hospitalization, the cost of analgesia and the self-rated Bruggrmann Comfort Scales (BCS) and incidence of adverse reactions were recorded. Results: There was no significant difference in the VAS scores of resting pain at 1, 6, 12, and 24 h after operation in group D and those in group T at the same time point (P>0.05), but the VAS scores for neck pain at the same time point were significantly lower than that in the traditional single mode analgesia group (P<0.05); Intraoperative remifentanil dosage and analgesia costs were significantly lower than those in the group T (all P values <0.05); the time to get out of bed for the first time after surgery, the time of first eating liquid, and self-evaluation comfort were significantly better than those in the group T (P value all <0.05); The levels of IL-6 at 24 hours after surgery in the two groups were significantly higher than those before surgery, but the increase in group D was lower than that in group T; the length of hospitalization in group D and the incidence of postoperative adverse reactions tended to be lower than those in group T, but the difference was not statistically significant (P>0.05). Conclusion: Compared with the traditional single analgesic mode, the sequential multi-mode analgesia based on ERAS concept can significantly improve the satisfaction of patients, reduce the dynamic pain score and the cost of postoperative analgesia, and promote the early recovery of patients.