组织因子途径抑制物调控细胞凋亡与冠心病
| 作者: |
1闫汝楠,
1李嘉舒,
1傅羽
1 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150001 |
| 通讯: |
傅羽
Email: 32375576@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.05.025 |
| 基金: | 国家自然科学基金(81200143，81200235)；黑龙江省自然科学基金(QC2012C015)；哈尔滨医科大学附属第一医院院基金(2015B002)。 |
摘要
细胞凋亡是机体的一种适应性反应，生理性的细胞凋亡对于细胞生长、生存及维持人体内环境稳定至关重要。然而过度凋亡可能促进冠状动脉粥样硬化、心肌缺血/再灌注损伤以及缺血后心脏重塑等。组织因子途径抑制物(tissue factor pathway inhibitor，TFPI)除了可以抗凝、抗栓，还具有诱导细胞凋亡的作用。因此，探讨冠心病中TFPI对细胞凋亡的影响，可为冠心病的治疗提供新的途径。
关键词：
组织因子途径抑制物；细胞凋亡；冠心病
Tissue factor pathway inhibitor regulating apoptosis and coronary artery disease
CorrespondingAuthor: FU Yu Email: 32375576@qq.com
DOI: 10.3978/j.issn.2095-6959.2021.05.025
Foundation: This work was supported by the National Natural Science Foundation of China (81200143, 81200235), the Natural Science Found of Heilongjiang projects (QC2012C015), and the Foundation of the First Affiliated Hospital of Harbin Medical University (2015B002), China.
Abstract
Apoptosis is an adaptive response in vivo. It plays a key role in cell growth, survival, and the maintenance of homeostasis in physiological conditions. However, excessive apoptosis may promote the processes of coronary atherosclerosis, myocardial ischemia/reperfusion injury, and post-ischemic cardiac remodeling. Tissue factor pathway inhibitor (TFPI) not only participate in the regulation of anticoagulation and antithrombosis, but can also induce cell apoptosis. Therefore, discussing the effect of TFPI on apoptosis in coronary artery disease would provide a new approach to the treatment of coronary artery disease.
Keywords：
tissue factor pathway inhibitor; apoptosis; coronary artery disease