白色脂肪组织在不同类型肥胖和代谢状态人群中的差异及作用
| 作者: |
1岳海清,
1周后德
1 中南大学湘雅二医院代谢内分泌科，国家代谢性疾病临床医学研究中心、代谢性骨病学湖南省重点实验室，长沙 410011 |
| 通讯: |
周后德
Email: houdezhou@csu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2021.06.034 |
| 基金: | 国家自然科学基金 (81970762, 81770880, 81800788)；湖南省科技厅项目 (2015JC3012, 2018SK52511)。 |
摘要
肥胖已日益成为严重的全球性健康问题，大部分肥胖可导致机体一系列代谢异常，此类肥胖被称为代谢异常型肥胖(metabolically unhealthy obesity，MUO)；还有一类虽然按体重指数标准被称之为肥胖，但机体代谢水平正常，被称为代谢正常型肥胖(metabolically healthy obesity，MHO)。不同类型肥胖和代谢状况人群间的具体差异和发病机制尚不明确。白色脂肪组织的向心性分布、异位累积，解剖学结构改变和能量代谢、内分泌功能的异常，以及细胞外基质重塑在肥胖代谢状态改变的发生发展过程中扮演了关键作用，从而成为不同类型肥胖发生的重要中间环节。
关键词：
脂肪组织；代谢正常型肥胖；代谢异常型肥胖
Difference and effect of white adipose tissue in different types of obesity and metabolic status
CorrespondingAuthor: ZHOU Houde Email: houdezhou@csu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2021.06.034
Foundation: This work was supported by the National Natural Scientific Foundation of China (81770880, 81800788, 81970762) and Science & Technology Department of Hunan Province (2015JC3012, 2018SK52511), China.
Abstract
Obesity is a rising threat to the global health. Most kinds of obesity are linked to a serious of metabolic diseases, which are considered as metabolically unhealthy obese (MUO). Besides, a distinct subset called metabolically healthy obesity (MHO) is characterized by the abnormal body mass index (BMI) and yet the absence of metabolic disturbances. Differences and mechanisms underlying the metabolic risks remain unclear in people with diverse types of obesity and metabolic status. Central and ectopic fat accumulation, impaired adipose tissue expandability and altered lipid metabolism of fat cells, and extracellular matrix remodeling play a key role in the development of obesity metabolism, and thus become an important intermediate link in the occurrence of obesity of different type population.
Keywords：
adipose tissue; metabolically healthy obesity; metabolically unhealthy obesity