抗生素缓释载体在慢性骨髓炎治疗中的应用进展
| 作者: |
1李善龙,
1从凯,
1尚剑,
2Pan Harry
1 哈尔滨医科大学附属第一医院骨外科，黑龙江 哈尔滨 150000 2 Abingdon School，Abingdon OX14 1DE，UK |
| 通讯: |
尚剑
Email: shj1616@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.04.032 |
摘要
慢性骨髓炎是骨科最难处理的疾病之一，通常采用静脉抗生素及清创等治疗方案，但也会带来全身药物毒副作用及部分骨缺损。抗生素缓释载体对病变部位具有靶向性、缓释性，能够代替全身抗生素应用，减少药物毒副作用，增加局部药物浓度，达到良好抑菌杀菌效果，同时具有骨传导及骨诱导性，有潜在的促进骨愈合及骨形成作用，为慢性骨髓炎的治愈带来了新的希望。
关键词：
抗生素载体；缓释；慢性骨髓炎；研究进展
Progress in the application of antibiotic sustained-release carrier in the treatment of chronic osteomyelitis
CorrespondingAuthor: SHANG Jian Email: shj1616@sina.com
DOI: 10.3978/j.issn.2095-6959.2021.04.032
Abstract
Chronic osteomyelitis is one of the most difficult diseases in orthopedics. Intravenous antibiotics and debridement are usually used to treat it, but it can also bring systemic drug side effects and some bone defects. The antibiotic sustained-release carrier is targeted and slow-released to the lesion site, which can replace the application of systemic antibiotics, reduce drug side effects, increase local drug concentration, achieve good bacteriostatic and bactericidal effect, and have bone conduction and bone induction. It has the potential to promote bone healing and bone formation, which brings new hope for the cure of chronic osteomyelitis.
Keywords：
antibiotic carrier; sustained-release; chronic osteomyelitis; research progress