抗GQ1b抗体阳性Miller-Fisher综合征1例
| 作者: |
1朱永云,
1吴崇民,
1保健见,
1尹蔚芳,
1殷康福,
1刘彬,
1王芳,
1任惠
1 昆明医科大学第一附属医院老年神经内科，昆明 650032 |
| 通讯: |
任惠
Email: rh-3338@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.02.037 |
| 基金: | 昆明医科大学-云南省科技厅联合专项[2019FE001(-048)]；国家自然科学基金项目(81960242)。 |
摘要
Miller-Fisher综合征(Miller-Fisher syndrome，MFS)是一种急性免疫相关性神经脱髓鞘疾病，是吉兰-巴雷综合征(Guillain-Barre syndrome，GBS)的一种临床变异型，其神经节苷脂抗GQ1b抗体检测通常为阳性。抗GQ1b IgG抗体在Bickerstaff脑干脑炎(Bickerstaff brainstem encephalitis，BBE)、GBS、急性眼外肌麻痹中亦有很高的阳性率，提示他们具有共同的免疫发病机制；Odaka等首次提出“抗GQ1b抗体综合征(anti-GQ1b antibody syndrome)”的概念，抗GQ1b抗体综合征临床表型多种多样，临床早期诊断较为困难。本报告描述了1例抗GQ1b抗体阳性的MFS，并复习抗GQ1b抗体综合征相关文献知识，为临床诊治提供方向。
关键词：
Miller-Fisher综合征；抗GQ1b IgG抗体；抗GQ1b抗体综合征
A case of Miller-Fisher syndrome with positive anti-GQ1b antibody
CorrespondingAuthor: REN Hui Email: rh-3338@163.com
DOI: 10.3978/j.issn.2095-6959.2021.02.037
Foundation: This work was supported by Kunming Medical University–Yunnan Provincial Science and Technology Department Joint Special Project [2019FE001(-048)] and the National Natural Science Foundation of China (81960242), China.
Abstract
Miller-Fisher syndrome (MFS) is an acute, immune-mediated demyelinating polyneuropathies (AIDP) and a clinical variant of Guillain-Barre syndrome (GBS). The detection for anti-GQ1b ganglioside antibody is usually positive. Anti-GQ1b IgG antibodies also have a high positive rate in Bickerstaff brainstem encephalitis (BBE), GBS, and acute extraocular muscle paralysis, suggesting that the letter three diseases have a common immune pathogenesis. Odaka et al. first proposed the concept of “anti-GQ1b antibody syndrome”. The clinical phenotype of anti-GQ1b antibody syndrome is diverse, and early clinical diagnosis is difficult. This report describes a case of MFS with positive anti-GQ1b antibody, and makes a review of anti-GQ1b antibody syndrome through collecting relevant literature knowledge to provide direction for clinical diagnosis and treatment.
Keywords：
Miller-Fisher syndrome；anti-GQ1b IgG antibody；anti-GQ1b antibody syndrome