Objective: To explore the nursing intervention effect of CICARE mode on cognitive impairment in patients with autoimmune encephalitis. Methods: A total of 66 patients diagnosed with autoimmune encephalitis (AE) at Xiangya Hospital of Central South University from December 2017 to June 2019 were enrolled, and they were randomly assigned into a control group and an observation group, 33 cases in each group. The control group was given routine specialized nursing, and the observation group was given CICARE communication mode for 14 days except for nursing. The cognitive function scores of the two groups were compared with themselves before and after intervention, including memory ability (MQ), intelligence quotient (IQ), and brain damage (DQ), mastery of disease knowledge and nursing ability score, nursing quality score and satisfaction rate. Results: Before intervention, cognitive function between the two groups has no statistical significance (P>0.05). After intervention, MQ and IQ scores in the two groups increased (both P<0.01) and DQ score decreased (P<0.05). In the observation group, the scores about mastery of disease knowledge and nursing ability were higher than those of the control group (both P<0.001). Compared with the control group, the quality and satisfaction of nursing service in the observation group were improved (both P<0.01). Conclusion: In patients with AE, providing nursing intervention with CICARE communication mode can greatly improve their cognitive function, enhance their mastery of disease knowledge and nursing ability, improve nursing service, and increase the patients’ satisfaction.