Objective: To retrieve and obtain evidence for the prevention and control of the complications of puncture points after the interventional treatment of femoral artery puncture, and provide clinical nurses with references to the targeted nursing. Methods: Evidence-based nursing was used to raise questions about the prevention and control of the complications of puncture points after the interventional treatment of femoral artery puncture. We retrieve the relevant literatures of the database and professional websites. The evaluation tools of the Australian JBI Evidence-based Healthcare Center in 2016, the JBI Evidence Pre-Classification 2014, and the Evidence Recommendation Level System were used to evaluate the quality of the literature and evaluate the evidence level. Results: After expert judgment, two systematic review papers and five systematic reviews were finally adopted, and 16 pieces of evidence were summarized to intervene throughout the perioperative period. Conclusion: This study summarizes the recent best evidence on the prevention and control of puncture point complications after interventional treatment of femoral artery puncture, which can provide evidence-based references for nurses and nursing managers. Through the application of the best evidence, scientific methods will be used to prevent and control the complications of puncture site after the interventional therapy of femoral artery puncture, so as to improve the quality of nursing.