药代动力学与血友病的个体化预防治疗
| 作者: |
1冉立,
1黎承平
1 昆明医科大学第一附属医院血液内科，昆明 650032 |
| 通讯: |
黎承平
Email: lcp0619@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.03.034 |
| 基金: | 云南省应用基础研究联合项目(2017NS047)。 |
摘要
血友病是一种由基因突变导致凝血因子缺乏引起的出血性疾病。由于血友病管理理念的不断发展，现在首选的治疗方案是预防治疗。凝血因子在不同患者体内的药代动力学以及不同患者的出血类型存在明显差异，可以根据患者药代动力学相关数据为其量身定做治疗方案，尽量减少患者的不便、不适以及尽可能避免高昂的治疗费用。因此，个体化预防是重要的。它可能使预防治疗的剂量更加准确，形成精准化治疗。
关键词：
血友病；药代动力学；个体化预防治疗
Pharmacokinetics and individualized prevention and treatment of hemophilia
CorrespondingAuthor: LI Chengping Email: lcp0619@163.com
DOI: 10.3978/j.issn.2095-6959.2021.03.034
Foundation: This work was supported by Joint Project of Applied Basic Research in Yunnan Province, China (2017NS047).
Abstract
Hemophilia is a hemorrhagic disease caused by a genetic mutation that leads to a deficiency of coagulation factors. Due to the continuous development of hemophilia management concept, the preferred treatment now is preventive treatment. There are significant differences in the pharmacokinetics of coagulation factors in different patients and the types of bleeding in different patients, and doctors can tailor the treatment according to the pharmacokinetic data of patients to minimize the inconvenience and discomfort of the patients and avoid high treatment costs as far as possible. Therefore, individualized prevention is important and may lead to more accurate doses of preventive treatment, which is conducive to precision treatment.
Keywords：
hemophilia; pharmacokinetics; individualized prevention and treatment