Objective: To study the curative effect of neuroendoscopy on hypertensive intracerebral hemorrhage (HICH) in basal ganglia. Methods: From January 2016 to December 2018, 50 patients with HICH in basal ganglia who were admitted to Zhangjiagang First People’s Hospital were selected. According to the treatment methods, they were divided into an observation group and a control group, each of 25 cases. The observation group used endoscopic hematoma clearance, and the control group used craniotomy hematoma clearance. Basic operation indexes and hematoma clearance, complications and mortality rate of the two groups were observed. The neurological deficit and life ability of the two groups before and after treatment were evaluated by the scales. Results: Postoperative residual volume and hematoma clearance rate of the observation group were better than those of the control group (P<0.05). Operation time, anesthesia time, intraoperative blood loss, ICU stay time, and hospitalization time were lower than those of the control group (P<0.05). The incidence of post-operative complications was lower than that of the control group (P<0.05), and the observation group scored better than the control group on the activities of daily living (ADL), functional independence measure (FIM), National Institute of Health stroke scale (NIHSS) scale 6 months after the operation (P<0.05). Conclusion: HICH in the basal ganglia area is better treated with neuroendoscopy, with higher hematoma clearance rate, fast postoperative recovery, relatively lower incidence of complications and good recovery of nerve function and daily living ability. The advantages of minimally invasive surgery are obvious.