巨噬细胞移动抑制因子在阻塞性睡眠呼吸暂停低通气综合征中的表达及与血管内皮损伤的相关性
| 作者: |
1宋涛,
2李晓栋,
1贾喆
1 秦皇岛军工医院综合内科，河北 秦皇岛 066000 2 秦皇岛市卫生学校药学教研室，河北 秦皇岛 066000 |
| 通讯: |
宋涛
Email: seurme@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.11.010 |
| 基金: | 秦皇岛市科学技术研究与发展计划(201805A134)。 |
摘要
目的：探讨巨噬细胞移动抑制因子(macrophage migration inhibition factor，MIF)在阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome，OSAHS)中的表达及与血管内皮损伤的相关性。方法：选择2016年9月至2018年9月在秦皇岛军工医院收治的OSAHS患者126例，按病情严重程度分为轻度组(n=42)、中度组(n=42)、重度组(n=42)；另选42例健康人群作为对照组。分析各组中MIF的表达情况及血管内皮损伤标志物的水平差异。结果：各组AHI、氧减指数、最低血氧饱和度水平比较，差异均有统计学意义(均P<0.05)。对照组AHI、氧减指数水平最低，随病情加重，逐渐升高，以重度组最高；对照组最低血氧饱和度水平最高，随病情加重，逐渐降低，以重度组最低(P<0.05)。各组MIF，TNF-α，IL-6，sVCM-1，ET，CPR，vWF水平比较，整体差异均有统计学意义(均P<0.05)，对照组MIF，TNF-α，IL-6，sVCM-1，ET，CPR，vWF水平最低，随病情加重，逐渐升高，以重度组最高(P<0.05)。MIF与OSAHS严重程度呈正相关(r=0.691，P<0.001)。MIF与AHI、氧减指数正相关，与最低血氧饱和度负相关(P<0.05)。MIF与TNF-a，IL-6，sVCM-1，ET，CPR，vWF存在不同程度正相关(P<0.05)。结论：OSAHS患者血清MIF水平随疾病的严重程度明显升高,与血管损伤相关因子具有正向相关性，提示MIF可能参与了OSAHS的炎性反应，在血管内皮损伤中起一定作用。
关键词：
Expression of macrophage migration inhibitory factor in obstructive sleep apnea hypopnea syndrome and its correlation with vascular endothelial injury
CorrespondingAuthor: SONG Tao Email: seurme@163.com
DOI: 10.3978/j.issn.2095-6959.2020.11.010
Foundation: This work was supported by the Qinhuangdao Science and Technology Research and Development Plan, China (201805A134).
Abstract
Objective: To investigate the expression of macrophage migration inhibition factor (MIF) in obstructive sleep apnea hypopnea syndrome (OSAHS) and its correlation with vascular endothelial injury. Methods: From September 2016 to September 2018, 126 patients with OSAHS were divided into the mild group (n=42), the moderate group (n=42) and the severe group (n=42) according to the severity of the disease, and 42 healthy people were selected as the control group. The expression of MIF and the level of vascular endothelial injury markers in each group were analyzed. Results: There were significant differences in AHI, oxygen reduction index and lowest oxygen saturation among the groups (all P<0.05). The control group had the lowest levels of AHI and Oxygen Reduction Index, and gradually increased with the aggravation of the disease, with the highest level in the severe group; the lowest level of oxygen saturation in the control group was the highest, with the aggravation of the disease, gradually decreased, with the lowest level in the severe group (P<0.05). The diffrences in the MIF, TNF-α, IL-6, sVCM-1, ET, CPR, and vWF levels were all statistically significant (all P<0.05); the MIF, TNF-α, IL-6, sVCM-1, CPR, vWF levels in the control group were the lowest, which gradually increased with the severity of the disease, the levels in the severe group were the highest (P<0.0.5). MIF was positively correlated with OSAHS severity (r=0.691, P<0.001). MIF was positively correlated with AHI and oxygen reduction index, and negatively correlated with the lowest oxygen saturation (P<0.05). MIF was positively correlated with TNF-α, IL-6, sVCM-1, ET, CPR and vWF (P<0.05). Conclusion: Serum MIF levels in OSAHS patients is significantly increased with the severity of the disease and positively correlated with vascular injury related factors, suggesting that MIF may participate in the inflammatory response of OSAHS and play a role in vascular endothelial injury.
Keywords：
obstructive sleep apnea hypopnea syndrome; macrophage migration inhibitory factor; vascular endothelium; inflammatory factor