富血小板血浆联合塞来昔布治疗膝关节骨性关节炎患者
| 作者: |
1陶金刚
1 新乡医学院附属第一医院骨外科，河南 新乡 453100 |
| 通讯: |
陶金刚
Email: shuiborujing@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.04.005 |
摘要
目的：研究富血小板血浆(platelet-rich plasma，PRP)联合塞来昔布治疗膝关节骨性关节炎(knee osteoarthritis，KOA)的临床效果。方法：选取新乡医学院附属第一医院2017年4月至2018年4月期间收治的KOA患者106例为研究对象，按随机数表法分为观察组和对照组，对照组给予PRP膝关节内注射治疗，观察组在对照组的基础上给予塞来昔布胶囊口服治疗，比较两组患者治疗后3个月后的临床疗效、视觉模拟疼痛评分(Visual Analog Scale，VAS)、Lequesne膝骨性关节炎严重度指数评分(Index of Severity for Osteoarthritis of Hip and Knee，ISOA)、Lysholm膝关节功能评分变化情况，治疗前后血清中软骨寡聚基质蛋白(cartilage oligomeric matrix protein，COMP)、基质金属蛋白酶-3(matrix metalloproteinase-3，MMP-3)、IL-1β、TNF-α水平，并记录治疗过程中的不良反应。结果：观察组患者的治疗总有效率94.34%(50/53)显著高于对照组的81.13%(43/53)(χ2=4.296，P=0.038)；治疗3个月后观察组患者的VAS、ISOA评分显著低于对照组，Lysholm膝关节功能评分显著高于对照组，且观察组患者血清中COMP、MMP-3、IL-1β、TNF-α水平也显著低于对照组，差异均有统计学意义(P<0.05)；两组治疗期间均未有明显不良反应发生。结论：PRP联合塞来昔布治疗KOA临床效果显著，能更好的改善患者膝关节功能及缓解关节疼痛，且安全性高。
关键词：
膝关节；骨性关节炎；富血小板血浆；塞来昔布
Platelet-rich plasma combined with celecoxib in treatment of patients with knee osteoarthritis
CorrespondingAuthor: TAO Jingang Email: shuiborujing@163.com
DOI: 10.3978/j.issn.2095-6959.2021.04.005
Abstract
Objective: To study clinical curative effect of platelet-rich plasma (PRP) combined with celecoxib on knee osteoarthritis (KOA). Methods: A total of 106 KOA patients admitted to the hospital from April 2017 to April 2018 were enrolled in the study. They were divided into observation group and control group by random number table method. The control group was treated with PRP intra-articular injection, while the observation group was given oral celecoxib capsules on the basis of control group. At 3 months after treatment, clinical curative effect, changes in scores of Visual Analog Scale (VAS), Index of Severity for Osteoarthritis of Hip and Knee (ISOA) and Lysholm knee function, levels of cartilage oligomeric matrix protein (COMP), matrix metalloproteinase-3 (MMP-3), IL-1β and TNF-α in serum before and after treatment were compared between the two groups. The adverse reactions during treatment were recorded. Results: The total response rate of treatment in observation group was significantly higher than that in control group [94.34% (50/53) vs (81.13% (43/53)] (χ2=4.296, P=0.038). At 3 months after treatment, scores of VAS and ISOA in observation group were significantly lower than those in control group, while score of Lysholm knee function was significantly higher than that in control group. The levels of COMP, MMP-3, IL-1β and TNF-α in serum of the observation group were also significantly lower than those in the control group (P<0.05). There were no significant adverse reactions during treatment in either group. Conclusion: The clinical curative effect of PRP combined with celecoxib is significant on KOA, which can better improve knee function and relieve joint pain, with high safety.
Keywords：
knee; osteoarthritis; platelet-rich plasma; celecoxib