应激诱导蛋白Sestrin2在多种病理过程中的作用研究进展
| 作者: |
1杨永,
1杨树森
1 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150001 |
| 通讯: |
杨树森
Email: yangss@vip.163.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.02.024 |
| 基金: | 哈尔滨市科技创新人才研究专项基金 (2016RAXYJ061)。 |
摘要
Sestrins是高度保守的应激诱导蛋白，可帮助维持代谢稳态并在应激条件下保护细胞。Sestrin2抑制氧化应激并调节AMP依赖的蛋白激酶-雷帕霉素靶点复合物(the AMP activated protein kinase - mammalian target of rapamycin complex，AMPK-mTORC)信号通路，在机体发生肿瘤、衰老退行性疾病、代谢性疾病、免疫性疾病时发挥保护作用。
关键词：
Sestrin2；AMP依赖的蛋白激酶-雷帕霉素靶点复合物；肿瘤；衰老；代谢；免疫
Research progress on the stress-induced protein Sestrin2 in several pathological process
CorrespondingAuthor: YANG Shusen Email: yangss@vip.163.com
DOI: 10.3978/j.issn.2095-6959.2021.02.024
Foundation: This work was supported by the Harbin Science and Technology Innovation Talent Research Foundation, China (2016RAXYJ061).
Abstract
Sestrins are highly conserved stress-inducible proteins that help maintain metabolic homeostasis and protect cells under stress conditions. The role of Sestrin2 inhibits oxidative stress and regulates the AMP activated protein kinase - mammalian target of rapamycin complex (AMPK-mTORC) signaling pathway, which protects the body from tumors, aging and degenerative diseases, metabolic diseases, and immune diseases.
Keywords：
Sestrin2; AMP activated protein kinase-mammalian target of rapamycin complex; tumors; senility; metabolic; immune