Objective: To explore the application of the new nursing mode of “continuous dynamic follow-up” under the concept of general practice and its influence on blood pressure (BP) indexes in elderly patients with hypertension. Methods: A total of 122 elderly patients with hypertension admitted to the Second People’s Hospital of Wuxi from February 2018 to April 2019 were selected as study subjects and divided into a control group and a study group by random number table, 61 cases in each group. All patients completed the follow-up visits and none lost to follow up. Control group received routine nursing, on which basis study group received the new nursing mode of “continuous dynamic follow-up” under the concept of general practice. The quality of life (QOL) scores, the satisfactory degree of nursing, the BP changes and PSMBRS dimension scores were observed and compared between two groups. Results: There were insignificant differences between two groups in QOL scores (P>0.05) before nursing interventions. After nursing interventions, QOL scores increased in both groups, which increased more significantly in study group than those in control group (P<0.05). Three months after nursing interventions, study group was notably superior to control group in PSMBRS dimension scores (P<0.05), and study group was evidently lower in systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P<0.05) and higher in the stability of SBP and DBP than control group. The satisfactory degree of nursing was 91.8% in study group, prominently higher than the 80.3% in control group (χ2=4.0060, P=0.0453). Conclusion: Application of the new nursing mode of “continuous dynamic follow-up” under the concept of general practice in the elderly patients with hypertension is better in clinical efficacy and can effectively improve patients’ BP and QOL and promote the satisfactory degree of nursing, thus deserving to be clinically popularized.