Objective: To explore the effect of external application of Evodia rutaecarpa combined with humanistic nursing on the sleep quality of schizophrenic patients, so as to provide guidance for the clinical diagnosis and treatment of patients. Methods: One hundred schizophrenics diagnosed with schizophrenia between July 2018 and July 2019 were selected for study. According to the random number table method, patients were divided into a control group and a study group (50 cases for each). The control group used conventional nursing, while the study group used external application of Evodia rutaecarpa combined with humanistic nursing. The sleep quality, quality of life and social cognitive function scores of the two groups were compared and analyzed before and after intervention, and the clinical effect was evaluated. Results: After intervention, the healthy behavior of patients in the study group was significantly improved than that in the control group (P<0.05); the sleep quality score of patients in the study group was 1.53±0.28, the life quality score was 16.3±5.11, the physical self-maintenance scale (PSMS) score was 21.3±5.9, and the instrumental activities of daily living scale (IADL) score was 5.12±4.28, which were significantly lower than that in the control group (sleep quality score 1.77±0.56, PSM score 19.12±6.67, PSMS score 26.3±5.97, IADL daily life activity score 9.17±1.28). The difference was statistically significant (P<0.05). The total effective rate of the study group was 98%, significantly higher than 64% of the control group. The difference was statistically significant (P<0.05). Conclusion: External application of Evodia rutaecarpa combined with humanistic nursing intervention has a significant effect on the sleep quality of schizophrenic patients, which can effectively improve the quality of life and sleep quality of patients, which is worthy of clinical promotion.