一氧化碳释放分子在基础医学中的应用
| 作者: |
1吴剑华,
1李彦霖,
1王一川,
1陈娜,
1杨雪亮,
1刘小静
1 西安交通大学第一附属医院感染科，西安 710061 |
| 通讯: |
刘小静
Email: xiaojing406@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.11.035 |
| 基金: | 国家重大科技基金项目(2017ZX10201201-001-004，2017ZX10201201-002-004，2017ZX10201201-004-003)。 |
摘要
随着一氧化碳(carbonic oxide，CO)的保护和治疗作用被发现，越来越多的研究将外源CO应用于临床治疗。一氧化碳释放分子(carbon monoxide releasing molecule，CORM)能稳定释放CO，在多领域实验研究中展现了调节细胞增殖、抗凋亡、抗炎、抗氧化等功能，有效地保护了动物机体及重要器官，有良好的应用前景。本文主要从血管扩张、抗炎、抗缺血再灌注、抗肿瘤等方面总结了当前CORM在基础医学中的应用研究进展，旨在探究其应用于临床治疗的潜力。
关键词：
一氧化碳释放分子；研究进展；炎症反应；缺血再灌注
Advances in basic research on exogenous carbon monoxide emission molecules
CorrespondingAuthor: LIU Xiaojing Email: xiaojing406@163.com
DOI: 10.3978/j.issn.2095-6959.2020.11.035
Foundation: This work was supported by the National Science and Technology Major Project Foundation, China (2017ZX10201201-001-004, 2017ZX10201201-002-004, 2017ZX10201201-004-003).
Abstract
With the discovery of protective and therapeutic effects of carbonic oxide (CO), more and more studies have applied exogenous CO in clinical treatment. Carbon monoxide releasing molecule (CORM) has a stable release of CO, and has demonstrated in many field experimental studies the functions of regulating cell proliferation, anti-apoptosis, anti-inflammatory and anti-oxidation, etc. and effectively protects the body and important organs of animals, showing a good application prospect. In this paper, the application of CORM in basic medicine was summarized from the aspects of vasodilation, anti-inflammatory, anti-ischemia-reperfusion and anti-tumor, so as to explore its potential in clinical treatment.
Keywords：
carbon monoxide releasing molecule; research progress; inflammatory response; ischemia-reperfusion