DNA构象多态性对肿瘤生物学行为影响的研究进展
| 作者: |
1苏晓丽,
1张声
1 福建医科大学附属第一医院病理科，福州 350005 |
| 通讯: |
张声
Email: zhgshg@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.02.025 |
| 基金: | 福建省自然科学基金(2015J01452)；福建省医学创新课题(2017-CX-28)。 |
摘要
获得性DNA损伤可导致体细胞基因突变或失活，与肿瘤的发生发展有关。传统的研究主要针对B-DNA双链结构中Watson-Crick碱基互补对的改变对DNA生物学的影响。而对DNA构象多态性(特殊DNA序列分子间或分子内氢键、不成对碱基配对等形成的多种非B-DNA三维立体空间结构)的研究尚少。对非B-DNA结构的生物学功能、转录、翻译、基因损伤及其与疾病发生发展关系的深入了解，可以提高人们对DNA三维立体空间结构对肿瘤生物学行为影响方面的认识。
关键词：
DNA构象多态性；非B-DNA结构；肿瘤生物学行为
Research progress in the effects of DNA conformation polymorphism on tumor biological behavior
CorrespondingAuthor: ZHANG Sheng Email: zhgshg@126.com
DOI: 10.3978/j.issn.2095-6959.2021.02.025
Foundation: This work was supported by the Natural Science Foundation of Fujian Province (2015J01452) and the Medical Innovative Subject of Fujian Province (2017-CX-28), China.
Abstract
Acquired DNA damage can lead to mutation or inactivation of somatic genes, which is related to the occurrence and development of tumors. Traditional research focused on the effects of changes in Watson-Crick complementary base pairs in B-DNA double-stranded structures on DNA biology. However, there are few studies focusing on the various three-dimensional spatial structures of non-B-DNA formed by intermolecular or intramolecular hydrogen bonding or unpaired base pairing of specific DNA sequences, that is, DNA conformation polymorphism. An in-depth knowledge of the biological functions, transcription, translation, gene damage of non B-DNA structures and its association between the occurrence and development of disease can improve the understanding of three-dimensional DNA structure’s impact on.
Keywords：
DNA conformation polymorphism; non-B-DNA structure; tumor biological behavior