Objective: To study the effect of applying a full range of health education models in the care of diabetic patients. Methods: A case-control study protocol was designed, and a total of 120 patients with type 2 diabetes were included in the implementation of the protocol and randomized into groups. In clinical nursing, the control group was provided with routine health education, and the observation group was provided with comprehensive health education. The mastery of diabetes-related knowledge and the effect of blood glucose control were taken as the main observational indicators of this study. Results: After the intervention, the observation group was higher than the control group in the scores of basic knowledge, risk factors, diet and exercise regulation, and knowledge of prevention of complications (P<0.05); and the average values of FBG, 2hPG, and HbAlc in the observation group They were lower than those in the control group (P<0.05). Conclusion: The application of full-scale health education in the care of diabetic patients can effectively improve the patient’s cognitive system and improve the effect of blood glucose control.