Skin cancer is the general term for malignant lesions of the skin, mainly including basal cell carcinoma, squamous cell carcinoma of the skin and malignant melanoma. Treatment mainly includes freezing, laser, electric cauterization, radiation and chemotherapy, local medication, surgery, etc., and surgical resection for the treatment of skin cancer is usually regarded as an ideal therapy. However, because the quantity of lesion, size, site and patient tolerance is different combined with the potential disease recurrence problem, the choice of operation scheme has certain restriction. Topical drug therapy can increase the drug level at the tumor site, which can be used for multiple or large skin lesions, and has less potential toxicity compared with systemic drugs. Therefore, it is a research hotspot in the treatment of skin cancer.